| Application | 4-methoxycyclohexylamine hydrochloride can be used as a pharmaceutical synthesis intermediate, such as the preparation of cis-8-methoxy-1, 3-diazaspiro [4,5]-decan-2, 4-dione: 40% ml of water was added to the autoclave, stirring was started, and G (2mol) of formamide was added, after stirring for 10min, add 130g(1mol) of 4-methoxycyclohexylamine hydrochloride, and then add 7g of carbon catalyst. Add CO into the reaction vessel, bring the pressure to 0.2MPa, and raise the temperature to 50 ℃, keep the temperature for 20h, when the content of 1-amino-4-methoxycyclohexane in the reaction solution is less than 2%, the reaction is finished, and the temperature is lowered to 25~30 ℃, dilute hydrochloric acid is added dropwise to the reaction solution, adjust the pH to 5~6, there are solid precipitation, filter out the product, filter cake wash once, cis-8-methoxy-1, 3-diazepine [4,5]-decan-2, 4-dione dry product 155g, yield 78%. |
